Search scope:
排序: Display mode:
Yun Zhang,Chen Li,Min Shen,Bao Liu,Xuejun Zeng,Ti Shen
Frontiers of Medicine 2017, Volume 11, Issue 1, Pages 62-67 doi: 10.1007/s11684-017-0498-7
Chronic disseminated intravascular coagulation (DIC) is a rare but devastating complication of aortic aneurysm (AA). This study investigated the clinical manifestations, laboratory findings, and treatment of patients with AA-associated chronic DIC (AA-DIC) and explored the mechanisms, duration, and therapeutic response of AA-DIC. We retrospectively reviewed the medical records of 235 AA patients admitted at the Peking Union Medical College Hospital between September 2009 and January 2015. The patients were classified as those with DIC (AA-DIC) and those without DIC (non-DIC). The AA-DIC group showed a significantly higher proportion of female patients and a significantly longer AA disease course than the non-DIC group did. The AA-DIC patients presented mural thrombi, dissecting aneurysms, a family history of AA, and diabetes significantly more frequently than the non-DIC patients did. Furthermore, multiple regression analyses revealed that sex, mural thrombus, aneurysm type, diabetes, and stent surgery are possible independent risk factors for AA-DIC patients. Fifty-two (22.1%) patients presented AA-DIC. Among these patients, 43 had non-typical DIC and 9 had typical DIC; the mortality rate of the latter was 22.2%. The mean age of the patients with typical DIC was significantly higher than of that of patients with non-typical DIC. The non-typical DIC patients also presented abnormal coagulation disorders of varying degrees. Furthermore, heparin or low-molecular-weight heparin improved the clinical symptoms and laboratory parameters in patients with AA and typical DIC. Thus, chronic DIC should be considered in patients with AA.
Keywords: aortic aneurysm disseminated intravascular coagulation anticoagulation therapy
How to judge the association of postmenopausal hormone therapy and the risk of breast cancer
Ling XU
Frontiers of Medicine 2010, Volume 4, Issue 3, Pages 290-293 doi: 10.1007/s11684-010-0093-7
Keywords: breast cancer postmenopausal hormone therapy unopposed estrogen therapy combined estrogen-progestin therapy
Particle therapy for cancers: a new weapon in radiation therapy
Guo-Liang Jiang
Frontiers of Medicine 2012, Volume 6, Issue 2, Pages 165-172 doi: 10.1007/s11684-012-0196-4
Keywords: radiation therapy particle therapy proton carbon cancer
Passive antibody therapy in emerging infectious diseases
Frontiers of Medicine doi: 10.1007/s11684-023-1021-y
Keywords: SARS-CoV-2 COVID-19 convalescent plasma hyperimmunoglobulin neutralizing monoclonal antibodies
mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?
Shi-Yong Sun
Frontiers of Medicine 2021, Volume 15, Issue 2, Pages 221-231 doi: 10.1007/s11684-020-0812-7
Keywords: mTOR cancer therapy resistance GSK3 protein degradation E3 ubiquitin ligase PD-L1
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
Frontiers of Medicine 2019, Volume 13, Issue 4, Pages 427-437 doi: 10.1007/s11684-018-0672-6
Keywords: targeted therapy desmoid-type fibromatosis tyrosine kinase inhibitor γ-secretase inhibitor
Hydroxyl radical-involved cancer therapy via Fenton reactions
Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 3, Pages 345-363 doi: 10.1007/s11705-021-2077-3
Keywords: hydroxyl radical Fenton catalyst hydrogen peroxide cancer therapy
Progress in systemic therapy for triple-negative breast cancer
Hongnan Mo, Binghe Xu
Frontiers of Medicine 2021, Volume 15, Issue 1, Pages 1-10 doi: 10.1007/s11684-020-0741-5
Keywords: triple-negative breast cancer immunotherapy targeted therapy
Translational medicine promising personalized therapy in oncology
Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,
Frontiers of Medicine 2010, Volume 4, Issue 4, Pages 351-355 doi: 10.1007/s11684-010-0320-2
Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 12, Pages 2144-2155 doi: 10.1007/s11705-023-2362-4
Keywords: copper sulfide nanoparticles chemodynamic therapy photothermal therapy carbon dots silica nanoparticles
Yang Wang, Huifang Zhou, Xianqun Fan
Frontiers of Medicine 2017, Volume 11, Issue 3, Pages 359-364 doi: 10.1007/s11684-017-0528-5
Keywords: thyroid-associated orbitopathy dysthyroid optic neuropathy orbital radiation therapy
Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity
Chuanfeng Wu, Cynthia E. Dunbar
Frontiers of Medicine 2011, Volume 5, Issue 4, Pages 356-371 doi: 10.1007/s11684-011-0159-1
Keywords: gene therapy hematopoietic stem cells insertional mutagenesis genotoxicity induced pluripotent stem cell
Molecular classification and molecular targeted therapy of cancer
Miao Xu, Jianyong Shao, Yixin Zeng
Frontiers of Medicine 2013, Volume 7, Issue 2, Pages 147-149 doi: 10.1007/s11684-013-0274-2
Frontiers of Medicine 2022, Volume 16, Issue 6, Pages 827-858 doi: 10.1007/s11684-022-0948-8
Keywords: infertility stem cell therapy mesenchymal stem cells pluripotent stem cells
Jiang Guoliang
Strategic Study of CAE 2009, Volume 11, Issue 10, Pages 129-136
Keywords: 3-dimensional conformal radiation therapy intensity modulated radiation therapy epatocellular carcinoma
Title Author Date Type Operation
Aortic aneurysm and chronic disseminated intravascular coagulation: a retrospective study of 235 patients
Yun Zhang,Chen Li,Min Shen,Bao Liu,Xuejun Zeng,Ti Shen
Journal Article
How to judge the association of postmenopausal hormone therapy and the risk of breast cancer
Ling XU
Journal Article
mTOR-targeted cancer therapy: great target but disappointing clinical outcomes, why?
Shi-Yong Sun
Journal Article
Targeted therapy of desmoid-type fibromatosis: mechanism, current situation, and future prospects
Zhen Wang, Jianhui Wu, Xiuyun Tian, Chunyi Hao
Journal Article
Progress in systemic therapy for triple-negative breast cancer
Hongnan Mo, Binghe Xu
Journal Article
Translational medicine promising personalized therapy in oncology
Yi-Xin ZENG, Xiao-Shi ZHANG, Qiang LIU,
Journal Article
Silica-based nanoarchitecture for an optimal combination of photothermal and chemodynamic therapy functions
Journal Article
The effect of orbital radiation therapy on thyroid-associated orbitopathy complicated with dysthyroid
Yang Wang, Huifang Zhou, Xianqun Fan
Journal Article
Stem cell gene therapy: the risks of insertional mutagenesis and approaches to minimize genotoxicity
Chuanfeng Wu, Cynthia E. Dunbar
Journal Article
Molecular classification and molecular targeted therapy of cancer
Miao Xu, Jianyong Shao, Yixin Zeng
Journal Article
Cell therapy for the treatment of reproductive diseases and infertility: an overview from the mechanism
Journal Article